Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TASP1 | Q9H6P5 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11695743 | 0.76 | NPC1 (0.74) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL11693290 | 0.72 | NPC1 (0.71) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL5180225 | 0.69 | GAA (0.74) | TASP1ALDH1A1GAATDP1NPC1 | |
| Hydrochloric Acid SCHEMBL11697560 | 0.68 | NPC1 (0.64) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL4257551 | 0.67 | GAA (0.58) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL6810880 | 0.65 | MEN1 (0.69) | TASP1ALDH1A1GAANPC1RAB9A | |
| SCHEMBL5181060 | 0.64 | GAA (0.66) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL5181419 | 0.64 | GAA (1.00) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL6843046 | 0.64 | ALDH1A1 (0.73) | TASP1ALDH1A1GAATDP1NPC1 | |
| SCHEMBL11692886 | 0.64 | NPC1 (0.52) | TASP1ALDH1A1GAATDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501811-B2 | TASPASE1 inhibitors and their uses | WASHINGTON UNIVERSITY (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | THE WASHINGTON UNIVERSITY (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | RNASE1, TASP1, PPA1 | TASP1 2/4885ALDH1A1 3123/4885GAA 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.