Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | BID | P55957 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068891 | 0.92 | TASP1 (1.00) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL7922643 | 0.84 | TASP1 (0.62) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL14096399 | 0.80 | TASP1 (0.64) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL14096381 | 0.77 | TASP1 (0.60) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL7920494 | 0.73 | TASP1 (0.56) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL7922259 | 0.73 | TASP1 (0.61) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL7922258 | 0.68 | MAPT (0.48) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL1062494 | 0.68 | TASP1 (0.48) | TASP1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL29410073 | 0.68 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19260918 | 0.68 | MAPT (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501811-B2 | TASPASE1 inhibitors and their uses | WASHINGTON UNIVERSITY (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | THE WASHINGTON UNIVERSITY (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015990-A1 | TASPASE1 INHIBITORS AND THEIR USES | RNASE1, TASP1, PPA1 | TASP1 2/4885MAPT 4457/4885ALDH1A1 3123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.