Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KLK7 | P49862 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | RGS4 | P49798 | 1/20 | 0.33 |
| ▸ | RGS8 | P57771 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069619 | 0.95 | KDM5B (0.34) | MAPTTP53CYP3A4 | |
| SCHEMBL10069631 | 0.91 | RGS4 (0.34) | ALDH1A1MAPK14RGS4RGS8GAA | |
| SCHEMBL10069611 | 0.90 | L3MBTL1 (0.36) | ALDH1A1USP2SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL10069594 | 0.90 | MAPT (0.38) | MAPTALDH1A1TP53USP2CYP1A2 | |
| SCHEMBL10069601 | 0.90 | ALDH1A1 (0.36) | ALDH1A1MAPK1CYP1A2CYP3A4MEN1 | |
| SCHEMBL10069598 | 0.86 | TP53 (0.33) | MAPTMAPK14P2RX3TP53 | |
| SCHEMBL10069629 | 0.83 | RGS4 (0.35) | MAPTALDH1A1RGS4RGS8TP53 | |
| SCHEMBL10069605 | 0.82 | CNR1 (0.34) | — | |
| SCHEMBL10069590 | 0.82 | ALDH1A1 (0.39) | ALDH1A1USP2MAPK1SMN1; SMN2LMNA | |
| SCHEMBL10069593 | 0.81 | MEN1 (0.35) | MAPK14P2RX3NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047993-A2 | N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-04-12 | — | — | WO | disclosed |