Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.36 |
| ▸ | HNF4A | P41235 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10041194 | 0.80 | CYP19A1 (0.33) | KDM4EMEN1KMT2APDE4BHSD17B10 | |
| SCHEMBL2018471 | 0.79 | FABP3 (0.47) | THRBGPR35ACMSDHNF4AMCL1 | |
| SCHEMBL1010666 | 0.76 | ACMSD (0.46) | THRBACMSDHNF4AMCL1DHFR | |
| SCHEMBL10041201 | 0.74 | — | — | |
| SCHEMBL17733182 | 0.74 | FABP3 (0.47) | THRBFABP3FABP4KDM4EMEN1 | |
| SCHEMBL5754427 | 0.73 | FABP4 (0.48) | THRBGPR35FABP3FABP4FABP5 | |
| SCHEMBL4572102 | 0.73 | THRB (0.45) | THRBGPR35ACMSDHNF4AMCL1 | |
| SCHEMBL1009517 | 0.73 | THRB (0.65) | THRBGPR35ACMSDHNF4AMCL1 | |
| SCHEMBL9899175 | 0.72 | SMN1; SMN2 (0.47) | THRBACMSDHNF4AMCL1DHFR | |
| SCHEMBL15492789 | 0.72 | ACMSD (0.38) | THRBGPR35ACMSDHNF4AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120161089-A1 | CHROMENE COMPOUND | TOKUYAMA CORPORATION (JP) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120161089-A1 | CHROMENE COMPOUND | CYP8B1, HSD3B2, CYP17A1 | THRB 1392/4885GPR35 1537/4885ACMSD 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.