Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768036 | 0.92 | PTGS2 (0.55) | ADRB2ADORA3CHRM1ADRA2BADRA2C | |
| SCHEMBL11482367 | 0.84 | NPC1 (0.61) | SIGMAR1NPC1RAB9AHPGDKDM4E | |
| SCHEMBL10674580 | 0.80 | NPC1 (0.69) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL9768141 | 0.80 | ALPL (0.48) | PTGS2TRPV1HDAC1MAPTHSD17B10 | |
| SCHEMBL11271218 | 0.80 | HDAC1 (0.45) | ADRB2ADORA3CHRM1ADRA2BADRA2C | |
| Acetic Acid SCHEMBL22551315 | 0.79 | ALPL (0.46) | PTGS2HDAC1MAPTKDM4EMEN1 | |
| Formic Acid SCHEMBL22551318 | 0.79 | MMP1 (0.46) | PTGS2ALOX15HDAC1RAB9AALDH1A1 | |
| Formic Acid SCHEMBL30892158 | 0.79 | MMP1 (0.46) | PTGS2ALOX15HDAC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11277285 | 0.78 | HDAC1 (0.44) | ADRB2ADORA3CHRM1ADRA2BADRA2C | |
| SCHEMBL9768043 | 0.78 | TRPV1 (0.49) | ALOX15TRPV1HDAC1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266817-B2 | Catecholamine derivatives for obesity and neurological disorders | EMORY UNIVERSITY (US) | 2016-02-23 | — | — | US | disclosed |
| US-20140329907-A1 | CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-11-06 | — | — | US | disclosed |
| US-20120022086-A1 | CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010107866-A2 | CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS | EMORY UNIVERSITY (US) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022086-A1 | CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS | BDNF, NTRK2, COMT | ADRB2 53/4885ADORA3 96/4885CHRM1 380/4885 |
| US-20140329907-A1 | CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS | BDNF, NTRK2, COMT | ADRB2 53/4885ADORA3 96/4885CHRM1 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.