Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709262 | 0.88 | SCN9A (0.52) | DRD4SCN9AFAAHALDH1A1TSHR | |
| SCHEMBL10072407 | 0.81 | DRD4 (0.72) | DRD4 | |
| SCHEMBL10072037 | 0.79 | SCN9A (0.62) | DRD4SCN9AALDH1A1MAPT | |
| SCHEMBL1286816 | 0.78 | DRD4 (0.62) | DRD4SCN9A | |
| SCHEMBL1709207 | 0.76 | SCN9A (0.54) | DRD4SCN9AALDH1A1LMNA | |
| SCHEMBL1709263 | 0.74 | SCN9A (0.53) | DRD4SCN9AALDH1A1LMNA | |
| SCHEMBL1709219 | 0.73 | SCN9A (0.74) | DRD4SCN9AALDH1A1LMNA | |
| SCHEMBL27979642 | 0.73 | HTT (0.89) | SMN1; SMN2HTTNPC1RAB9AGRIN2B | |
| SCHEMBL10072167 | 0.73 | SCN9A (0.61) | DRD4SCN9AALDH1A1 | |
| SCHEMBL1709274 | 0.72 | ALDH1A1 (0.53) | SMN1; SMN2DRD4SCN9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |