Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467872 | 0.72 | ALDH1A1 (0.49) | GFERATMKMT2AMEN1GPR183 | |
| SCHEMBL2701335 | 0.71 | ATM (0.59) | GFERATMKMT2AMEN1GPR183 | |
| SCHEMBL18298031 | 0.69 | NAMPT (0.48) | NAMPTKMT2AMEN1HSD11B1 | |
| SCHEMBL13149275 | 0.69 | ALDH1A1 (0.77) | GFERATMKMT2AMEN1GPR183 | |
| SCHEMBL17389537 | 0.68 | NAMPT (1.00) | NAMPT | |
| SCHEMBL1709237 | 0.68 | SCN9A (0.58) | NAMPT | |
| SCHEMBL10071959 | 0.67 | CCR3 (0.51) | ATMKMT2AMEN1 | |
| SCHEMBL2471161 | 0.67 | ALDH1A1 (0.55) | KMT2AMEN1EPHX1EPHX2MAPT | |
| SCHEMBL11076871 | 0.66 | GFER (0.89) | NAMPTGFERATMKMT2AMEN1 | |
| SCHEMBL7430480 | 0.66 | HPGD (0.67) | GFERATMKMT2AMEN1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |