Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709237 | 0.82 | SCN9A (0.58) | SCN9ASMN1; SMN2 | |
| SCHEMBL10071960 | 0.76 | SCN9A (0.49) | CCR3SCN9AMEN1KMT2AGAA | |
| SCHEMBL1709243 | 0.72 | SCN9A (0.52) | SCN9AMEN1KMT2AUSP2CYP3A4 | |
| SCHEMBL7899024 | 0.70 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BGAAALDH1A1 | |
| SCHEMBL4614753 | 0.69 | MEN1 (0.71) | MEN1KMT2AGAAATMBCHE | |
| SCHEMBL1709217 | 0.69 | SCN9A (0.48) | SCN9AKMT2AALDH1A1 | |
| SCHEMBL10072038 | 0.69 | SCN9A (0.53) | SCN9AMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL1709241 | 0.68 | SCN9A (0.54) | SCN9AUSP2ALDH1A1CYP3A4 | |
| SCHEMBL18840909 | 0.67 | CCR3 (1.00) | CCR3 | |
| SCHEMBL10072040 | 0.67 | NAMPT (0.52) | MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |