Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.89 |
| ▸ | ATM | Q13315 | 1/20 | 0.89 |
| ▸ | ME2 | P23368 | 2/20 | 0.77 |
| ▸ | ME1 | P48163 | 2/20 | 0.77 |
| ▸ | ME3 | Q16798 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | GRM5 | P41594 | 1/20 | 0.70 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | GPR183 | P32249 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706289 | 0.89 | ME2 (0.82) | GFERATMME2ME1ME3 | |
| SCHEMBL10902216 | 0.87 | GFER (0.78) | GFERATMME2ME1ME3 | |
| SCHEMBL2767151 | 0.87 | ME2 (1.00) | GFERATMME2ME1ME3 | |
| SCHEMBL23244223 | 0.87 | ME3 (1.00) | GFERATMME2ME1ME3 | |
| SCHEMBL2824683 | 0.86 | MAPT (1.00) | GFERATMME2ME1ME3 | |
| SCHEMBL28924200 | 0.85 | ME2 (0.76) | GFERATMME2ME1ME3 | |
| SCHEMBL25047094 | 0.85 | ME2 (0.76) | GFERATMME2ME1ME3 | |
| SCHEMBL1906328 | 0.82 | GRM5 (1.00) | GFERATMMEN1KMT2AMAPT | |
| SCHEMBL13149275 | 0.82 | ALDH1A1 (0.77) | GFERATMMEN1KMT2AHTR7 | |
| SCHEMBL10722408 | 0.82 | HSD11B1 (0.77) | GFERATMME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |