Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071959 | 0.82 | CCR3 (0.51) | SCN9ASMN1; SMN2 | |
| SCHEMBL10071960 | 0.80 | SCN9A (0.49) | SCN9ANAMPT | |
| SCHEMBL1709243 | 0.75 | SCN9A (0.52) | SCN9AHTR2A | |
| SCHEMBL1709210 | 0.73 | HTR1A (0.62) | SCN9ASIGMAR1HTR1ADRD2NAMPT | |
| SCHEMBL1709236 | 0.73 | SCN9A (1.00) | SCN9ASIGMAR1SMN1; SMN2HTR1ADRD2 | |
| SCHEMBL1709217 | 0.71 | SCN9A (0.48) | SCN9AHTR2A | |
| SCHEMBL10072038 | 0.71 | SCN9A (0.53) | SCN9A | |
| SCHEMBL1709249 | 0.70 | DRD4 (0.60) | SCN9ASIGMAR1HTR2AHTR1ADRD2 | |
| SCHEMBL1709241 | 0.70 | SCN9A (0.54) | SCN9ASIGMAR1DRD2 | |
| SCHEMBL1709252 | 0.69 | SCN9A (0.56) | SCN9ASIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |