SCHEMBL10072217

SCHEMBL10072217

COC(=O)COCc1ccc(N(c2ccc(C)c(C)c2)c2ccc(-c3ccc(N(c4ccc(CCOC(=O)OC)cc4)c4ccc(C)c(C)c4)c(C)c3)cc2C)cc1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.34
MAPT P10636 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL279187 0.91 MAPT (0.35) MAPTSMN1; SMN2
SCHEMBL279583 0.85 RARB (0.37) MAPTSMN1; SMN2
SCHEMBL279030 0.84 ALDH1A1 (0.36) MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL2810605 0.80 GPR88 (0.38) HRH3MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL8013965 0.80 GPR88 (0.38) HRH3MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL8059103 0.78 RAB9A (0.48) MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL279507 0.77 KDM4E (0.37) MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL2602478 0.77 THRB (0.35) SMN1; SMN2
SCHEMBL14063409 0.76 ALDH1A1 (0.40) MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL14063411 0.75 MCL1 (0.36) MAPTNPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8110328-B2 Conductive support with photosensitive layer containing curable resin, fluorinated surfactants and charge transfer compound FUJI XEROX CO., LTD. (JP) 2012-02-07 US disclosed
US-8110328-B2 Conductive support with photosensitive layer containing curable resin, fluorinated surfactants and charge transfer compound FUJI XEROX CO., LTD. (JP) 2012-02-07 US disclosed
US-20080261135-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2008-10-23 US disclosed
US-20080261135-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2008-10-23 US disclosed