SCHEMBL10077145

SCHEMBL10077145

CC(C)=CC(c1ccc(F)cc1)C(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.37
TRPA1 O75762 1/20 0.34
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
IDO1 P14902 1/20 0.32
TDO2 P48775 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL903568 0.84 ESR1 (0.43) LMNA
SCHEMBL13146772 0.81 PTGS1 (0.39)
SCHEMBL10077946 0.81 CYP1A2 (0.40) LMNA
SCHEMBL12448026 0.81 CYP1A2 (0.40) LMNA
SCHEMBL13063293 0.80 TRPA1 (0.40) AOC3TRPA1LMNA
SCHEMBL13588182 0.78 ALDH1A1 (0.43) AOC3LMNA
SCHEMBL14619687 0.77 CYP3A4 (0.36) TP53
SCHEMBL10248843 0.77 ACACB (0.41)
SCHEMBL10125275 0.77 NR1H4 (0.42) TP53
SCHEMBL14192207 0.74 L3MBTL1 (0.36) AOC3TRPA1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2412733-A1 Polymer, chemically amplified negative resist composition, and patterning process Shin-Etsu Chemical Co., Ltd. (JP) 2012-02-01 EP disclosed