SCHEMBL10078734

SCHEMBL10078734

Brc1ccc(OC2CCNCc3occc32)c2ccccc12

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.32
GID4 Q8IVV7 1/20 0.31
PKM P14618 1/20 0.30
PNMT P11086 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2840335 0.99 HTR6 (0.31) HTR6GID4
Hydrochloric Acid SCHEMBL2841018 0.87 PKM (0.31) PKM
SCHEMBL10078745 0.85 GID4 (0.33) GID4
Hydrochloric Acid SCHEMBL2839303 0.84 HTR2C (0.33) GID4
SCHEMBL2844093 0.83 IMPDH2 (0.39) PNMT
Hydrochloric Acid SCHEMBL3570724 0.82 IMPDH2 (0.39) PNMT
SCHEMBL10078647 0.81 MKNK1 (0.33) HTR6
SCHEMBL10078500 0.81 PKM (0.31) PKM
Hydrochloric Acid SCHEMBL2841723 0.81 MKNK1 (0.33) HTR6
Hydrochloric Acid SCHEMBL2841127 0.80 PKM (0.30) PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8217031-B2 Heteroaryl derivatives NIPPON SHINYAKU CO., LTD. (JP) 2012-07-10 US claimed