SCHEMBL10084157

SCHEMBL10084157

COc1ccc(CCNC(=O)/C=C/c2ccc(O)cc2)cc1

nearest known ligand 0.80

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.73
MAPT P10636 3/20 0.73
MMP1 P03956 2/20 0.70
MMP2 P08253 2/20 0.70
MMP9 P14780 2/20 0.70
LMNA P02545 2/20 0.68
MEN1 O00255 1/20 0.68
KMT2A Q03164 1/20 0.68
TAAR1 Q96RJ0 1/20 0.66
BCHE P06276 1/20 0.65
ACHE P22303 1/20 0.65
POLB P06746 1/20 0.62
PLAAT3 P53816 1/20 0.61
PLAAT5 Q96KN8 1/20 0.61
PLAAT2 Q9NWW9 1/20 0.61
PLAAT4 Q9UL19 1/20 0.61
CNR2 P34972 1/20 0.61
CYP1A2 P05177 1/20 0.60
CYP2C19 P33261 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N-P-Coumaroyl Tyramine SCHEMBL2512193 0.89 MMP1 (0.86) MAPTMMP1MMP2MMP9BCHE
N-P-Coumaroyl Tyramine SCHEMBL19551426 0.89 MMP1 (0.86) MAPTMMP1MMP2MMP9BCHE
SCHEMBL22422964 0.88 ALDH1A1 (0.77) ALDH1A1MAPTMMP1MMP2MMP9
SCHEMBL802711 0.87 CYP3A4 (0.70) ALDH1A1MAPTMMP1MMP2MMP9
SCHEMBL15970703 0.86 MAPT (0.69) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL15970702 0.86 MAPT (0.69) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL30925683 0.86 APP (0.75) ALDH1A1MAPTMMP1MMP2MMP9
SCHEMBL802992 0.84 MAPT (0.83) ALDH1A1MAPTMMP1MMP2MMP9
SCHEMBL14360890 0.84 MAPT (0.87) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL14477053 0.84 MAPT (1.00) ALDH1A1MAPTLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9295624-B2 Amide derivative and whitening agent AJINOMOTO CO., INC. (JP) 2016-03-29 US disclosed
EP-2412701-B1 NOVEL AMIDE DERIVATIVE AND SKIN WHITENING AGENT AJINOMOTO KK (JP) 2015-08-12 EP disclosed
US-20140255327-A1 NOVEL AMIDE DERIVATIVE AND WHITENING AGENT AJINOMOTO CO. INC. (JP) 2014-09-11 US disclosed
EP-2412701-A1 NOVEL AMIDE DERIVATIVE AND SKIN WHITENING AGENT Ajinomoto Co., Inc. (JP) 2012-02-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140255327-A1 NOVEL AMIDE DERIVATIVE AND WHITENING AGENT CUTA, NAT1, TYR ALDH1A1 163/4885MAPT 1419/4885MMP1 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.