Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12900304 | 0.78 | MAPT (0.44) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL28777044 | 0.76 | RAB9A (0.43) | MAPTNPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL4583536 | 0.75 | HTR3A (0.44) | SMN1; SMN2ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL12900291 | 0.74 | TOP2A (0.47) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL12900251 | 0.70 | MAPT (0.48) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL12932024 | 0.68 | LMNA (0.45) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL6297297 | 0.67 | ELANE (0.45) | MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL12252221 | 0.65 | DHFR (0.52) | MAPTSMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL1271524 | 0.65 | SMN1; SMN2 (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL7302599 | 0.64 | TOP2A (0.47) | MAPTSMN1; SMN2TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460787-A1 | Amide compounds and their use as PGE2 antagonists. | Astellas Pharma Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| EP-2172447-A1 | AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2010-04-07 | — | — | EP | disclosed |