Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984788 | 0.85 | EHMT2 (0.47) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL19188184 | 0.83 | HDAC1 (0.47) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL25413647 | 0.83 | ALDH1A1 (0.47) | ALDH1A1EHMT2EHMT1APOBEC3GHDAC1 | |
| SCHEMBL25413645 | 0.83 | ALDH1A1 (0.47) | ALDH1A1EHMT2EHMT1APOBEC3GHDAC1 | |
| SCHEMBL4349165 | 0.82 | ALDH1A1 (0.43) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL1120030 | 0.82 | ALDH1A1 (0.43) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL31005446 | 0.82 | ALDH1A1 (0.43) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL14868086 | 0.82 | EHMT2 (0.53) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL24378432 | 0.81 | HDAC1 (0.48) | ALDH1A1EHMT2EHMT1APOBEC3GSMN1; SMN2 | |
| SCHEMBL10340548 | 0.80 | LMNA (0.50) | ALDH1A1SMN1; SMN2HDAC1HDAC2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153504-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | ImmunoGen, Inc. (US) | 2017-04-12 | — | — | EP | disclosed |
| EP-2648510-B1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | IMMUNOGEN INC (US) | 2016-08-31 | — | — | EP | disclosed |
| US-9242936-B2 | Methods for the preparation of charged crosslinkers | IMMUNOGEN, INC. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150166482-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | IMMUNOGEN, INC. | 2015-06-18 | — | — | US | disclosed |
| US-8921566-B2 | Methods for the preparation of charged crosslinkers | IMMUNOGEN, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140135502-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | IMMUNOGEN, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20120165537-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | IMMUNOGEN, INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135502-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | SCLY, STOM, STS | ALDH1A1 1316/4885EHMT2 430/4885EHMT1 453/4885 |
| US-20150166482-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | SCLY, STOM, STS | ALDH1A1 1316/4885EHMT2 430/4885EHMT1 453/4885 |
| US-20120165537-A1 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS | SCLY, STOM, STS | ALDH1A1 1316/4885EHMT2 430/4885EHMT1 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.