SCHEMBL10089932

SCHEMBL10089932

Cc1cc(C#N)cc(C(=O)NCc2ccc(OC(F)F)cc2)c1NC(=O)c1cc(Cn2nnc(C(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GPR6 P46095 2/20 0.36
PPARG P37231 2/20 0.35
NR1I2 O75469 1/20 0.35
ELANE P08246 1/20 0.32
SLC2A1 P11166 3/20 0.32
SLC2A3 P11169 3/20 0.32
SLC2A4 P14672 3/20 0.32
SLC2A2 P11168 1/20 0.32
CPT1A P50416 1/20 0.32
CPT1B Q92523 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
PDE5A O76074 2/20 0.31
MMP13 P45452 2/20 0.31
GLS O94925 1/20 0.31
MT-CO2 P00403 1/20 0.30
KDM5B Q9UGL1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089881 0.95 GPR6 (0.36) GPR6PPARGNR1I2ELANEPDE5A
SCHEMBL10089991 0.93 GPR6 (0.36) GPR6ELANESLC2A1SLC2A3SLC2A4
SCHEMBL10089909 0.93 PPARG (0.36) GPR6PPARGNR1I2CPT1ACPT1B
SCHEMBL10089975 0.92 SLC2A1 (0.35) GPR6PPARGNR1I2ELANESLC2A1
SCHEMBL10090004 0.90 GPR6 (0.38) GPR6PDE5A
SCHEMBL10090032 0.90 GPR6 (0.36) GPR6GLS
SCHEMBL13085263 0.89 ALDH1A1 (0.32) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085295 0.89 SLC2A1 (0.32) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085290 0.89 PIN1 (0.33) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL13085292 0.88 KCNH2 (0.32) GPR6SLC2A1SLC2A3SLC2A4SLC2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 GPR6 2424/4885PPARG 3227/4885NR1I2 2630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.