Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012425 | 0.82 | TBXA2R (0.41) | ALDH1A1SMN1; SMN2TBXA2RPTGDRPTGDR2 | |
| SCHEMBL1010306 | 0.82 | PTGDR2 (0.51) | ALDH1A1SMN1; SMN2TBXA2RPTGDRPTGDR2 | |
| SCHEMBL12569006 | 0.78 | TBXA2R (0.42) | ALDH1A1SMN1; SMN2TBXA2RPTGDRPTGDR2 | |
| SCHEMBL1009772 | 0.76 | NR1H4 (0.48) | TBXA2RPTGDRPTGDR2NR1H4 | |
| SCHEMBL8738530 | 0.75 | PTGDR2 (0.49) | ALDH1A1SMN1; SMN2TBXA2RPTGDRPTGDR2 | |
| SCHEMBL1010222 | 0.73 | TBXA2R (0.38) | ALDH1A1TBXA2RPTGDRPTGDR2EGLN1 | |
| SCHEMBL1009043 | 0.70 | COPS5 (0.40) | ALDH1A1EGLN1MAPTL3MBTL1LMNA | |
| SCHEMBL1922623 | 0.69 | POLB (0.40) | SMN1; SMN2 | |
| SCHEMBL1010635 | 0.69 | POLB (0.40) | SMN1; SMN2 | |
| SCHEMBL1010897 | 0.69 | PTGDR2 (0.72) | TBXA2RPTGDRPTGDR2NR1H4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |