Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 3/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AS3MT | Q9HBK9 | 2/20 | 0.36 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095573 | 0.85 | ALDH1A1 (0.43) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL10095618 | 0.85 | KDM4E (0.41) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL10095946 | 0.85 | ESR1 (0.46) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL10095446 | 0.83 | GRIK2 (0.62) | GRIK2GRIK1KDM4EALDH1A1MAPT | |
| SCHEMBL10097247 | 0.81 | PGR (0.44) | GRIK2GRIK1ALDH1A1AS3MTPFKFB2 | |
| SCHEMBL10193331 | 0.80 | KDM4E (0.40) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL10095637 | 0.78 | GRIK2 (0.51) | GRIK2GRIK1KDM4EHPGDMAPT | |
| SCHEMBL12334234 | 0.78 | PGR (0.46) | GRIK2GRIK1KDM4EMAPK1AS3MT | |
| SCHEMBL2881906 | 0.78 | KDM4E (0.41) | GRIK2GRIK1KDM4EALDH1A1HPGD | |
| SCHEMBL10096216 | 0.77 | AS3MT (0.61) | GRIK2GRIK1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | PTC THERAPEUTICS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | HAVCR2, SERPINB1, ENPEP | GRIK2 4491/4885GRIK1 4307/4885KDM4E 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.