Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.44 |
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334234 | 0.89 | PGR (0.46) | PGRNR3C1NR3C2ARPFKFB2 | |
| SCHEMBL10095574 | 0.87 | KIF11 (0.45) | PGRNR3C1NR3C2ARNPC1 | |
| SCHEMBL10095620 | 0.87 | PGR (0.44) | PGRNR3C1NR3C2ARNPC1 | |
| SCHEMBL10252519 | 0.87 | BRPF1 (0.37) | PGRNR3C1NR3C2ARPFKFB2 | |
| SCHEMBL10095449 | 0.85 | GRIK2 (0.54) | PGRNR3C1NR3C2ARNPC1 | |
| SCHEMBL10095551 | 0.84 | CYP11B2 (0.47) | PGRNR3C1NR3C2ARNPC1 | |
| SCHEMBL10193421 | 0.83 | PGR (0.48) | PGRNR3C1NR3C2ARCYP11B2 | |
| SCHEMBL10095782 | 0.83 | MTOR (0.44) | PGRNR3C1NR3C2ARALDH1A1 | |
| SCHEMBL10095663 | 0.81 | GRIK2 (0.45) | PGRNR3C1NR3C2ARNPC1 | |
| SCHEMBL979533 | 0.81 | PGR (0.47) | PGRNR3C1NR3C2ARCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | PTC THERAPEUTICS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| US-8013006-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | OAT, HAVCR2, HCCS | PGR 3811/4885NR3C1 2338/4885NR3C2 2954/4885 |
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | HAVCR2, SERPINB1, ENPEP | PGR 3813/4885NR3C1 4099/4885NR3C2 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.