Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 5/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | IL6 | P05231 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010124 | 1.00 | NFKB1 (0.54) | NFKB1RXRAFBP1TLR4TLR2 | |
| SCHEMBL15056166 | 0.78 | FBP1 (0.50) | RXRAFBP1TLR4TLR2MAOB | |
| SCHEMBL15056165 | 0.78 | FBP1 (0.50) | RXRAFBP1TLR4TLR2MAOB | |
| SCHEMBL28627478 | 0.77 | FBP1 (0.49) | RXRAFBP1TLR4TLR2MAOB | |
| SCHEMBL28627476 | 0.77 | FBP1 (0.49) | RXRAFBP1TLR4TLR2MAOB | |
| SCHEMBL470811 | 0.76 | NFE2L2 (0.58) | RXRAFBP1TLR4TLR2PRMT1 | |
| SCHEMBL30914655 | 0.76 | NFE2L2 (0.58) | RXRAFBP1TLR4TLR2PRMT1 | |
| SCHEMBL4723192 | 0.76 | NFE2L2 (0.58) | RXRAFBP1TLR4TLR2PRMT1 | |
| SCHEMBL29072766 | 0.74 | TLR4 (0.56) | RXRAFBP1TLR4TLR2MAOB | |
| SCHEMBL29072764 | 0.74 | TLR4 (0.56) | RXRAFBP1TLR4TLR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110245223-A1 | HETEROCYCLIC COMPOUNDS | JAPAN TOBACCO INC. (JP) | 2011-10-06 | — | — | US | claimed |
| EP-1889842-A1 | HETEROCYCLIC COMPOUND | Japan Tobacco, Inc. (JP) | 2008-02-20 | — | — | EP | claimed |
| US-20070072908-A1 | Heterocyclic compounds | JAPAN TOBACCO INC. (JP) | 2007-03-29 | — | — | US | claimed |
| US-7132219-B2 | Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition | BREWER SCIENCE INC. (US) | 2006-11-07 | — | — | US | claimed |
| EP-1397260-A4 | POLYMERIC ANTIREFLECTIVE COATINGS DEPOSITED BY PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION | BREWER SCIENCE INC (US) | 2006-03-08 | — | — | EP | claimed |
| EP-1397260-A1 | POLYMERIC ANTIREFLECTIVE COATINGS DEPOSITED BY PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION | Brewer Science, Inc. (US) | 2004-03-17 | — | — | EP | claimed |
| US-20030219541-A1 | Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition | BREWER SCIENCE, INC. | 2003-11-27 | — | — | US | claimed |
| US-20030064608-A1 | Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition | SABNIS RAM W (US) | 2003-04-03 | — | — | US | claimed |
| US-20030054117-A1 | Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition | BREWER SCIENCE, INC. | 2003-03-20 | — | — | US | claimed |
| WO-2002062593-A1 | POLYMERIC ANTIREFLECTIVE COATINGS DEPOSITED BY PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION | BREWER SCIENCE, INC. (US) | 2002-08-15 | — | — | WO | claimed |
| US-5897940-A | Ink jet transparencies | XEROX CORPORATION (US) | 1999-04-27 | — | — | US | claimed |
| US-5744273-A | Laminatable backing substrates containing fluoro compounds for improved toner flow | XEROX CORPORATION (US) | 1998-04-28 | — | — | US | claimed |
| CN-112409408-A | Chiral phosphorus sulfur compound and Michael addition method thereof | 深圳湾实验室坪山生物医药研发转化中心 | 2021-02-26 | — | — | CN | disclosed |
| EP-2770987-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2900223-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2900223-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20030054117-A1 | Polymeric antireflective coatings deposited by plasma enhanced chemical vapor deposition | BREWER SCIENCE, INC. | 2003-03-20 | — | — | US | disclosed |
| WO-2002062593-A1 | POLYMERIC ANTIREFLECTIVE COATINGS DEPOSITED BY PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION | BREWER SCIENCE, INC. (US) | 2002-08-15 | — | — | WO | disclosed |
| US-5897940-A | Ink jet transparencies | XEROX CORPORATION (US) | 1999-04-27 | — | — | US | disclosed |
| US-5744273-A | Laminatable backing substrates containing fluoro compounds for improved toner flow | XEROX CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245223-A1 | HETEROCYCLIC COMPOUNDS | HSD11B1, HSD11B2, CYP11B1 | NFKB1 345/4885RXRA 1283/4885FBP1 1639/4885 |
| US-20070072908-A1 | Heterocyclic compounds | HSD11B1, HSD11B2, CYP11B1 | NFKB1 345/4885RXRA 1283/4885FBP1 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.