Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387610 | 0.88 | HDAC2 (0.43) | GPR119 | |
| SCHEMBL22266048 | 0.83 | HDAC2 (0.41) | GPR119 | |
| SCHEMBL7534118 | 0.83 | HDAC2 (0.43) | GPR119 | |
| SCHEMBL3385458 | 0.82 | MEN1 (0.43) | S1PR2 | |
| SCHEMBL2427136 | 0.81 | RORC (0.44) | GPR119 | |
| SCHEMBL1010791 | 0.81 | GPR119 (0.43) | GPR119S1PR2 | |
| SCHEMBL14077925 | 0.79 | S1PR2 (0.41) | S1PR2 | |
| SCHEMBL4293214 | 0.79 | OPRM1 (0.49) | GPR119 | |
| SCHEMBL15804317 | 0.79 | MEN1 (0.45) | S1PR2 | |
| SCHEMBL1669692 | 0.78 | GPR119 (0.42) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501777-B2 | 1-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]piperidine; central nervous system disorders, Parkinson's disease, Parkinsonism, dyskinesias, including L-DOPA induced dyskinesias, dystonias, tics, tremor, Huntington disease | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2013-08-06 | — | — | US | disclosed |
| US-8501777-B2 | 1-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]piperidine; central nervous system disorders, Parkinson's disease, Parkinsonism, dyskinesias, including L-DOPA induced dyskinesias, dystonias, tics, tremor, Huntington disease | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2013-08-06 | — | — | US | disclosed |
| EP-1948606-B1 | 3, 5-DISUBSTITUTED PHENYL-PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-01-05 | — | — | EP | disclosed |
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SANIONA AB (DK) | 2008-09-25 | — | — | US | disclosed |
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SANIONA AB (DK) | 2008-09-25 | — | — | US | disclosed |
| WO-2007042295-A1 | 3, 5-DISUBSTITUTED PHENYL-PIPERIDINES AS MDULATORS OF DOPAMINE? NEUROTRANSMISSION | NEUROSEARCH SWEDEN AB (SE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SLC6A3, DRD2, DRD3 | GPR119 265/4885S1PR2 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.