Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12535480 | 0.90 | GABRB3 (0.40) | RAPGEF4GABRB3NOTUMRXRARXRB | |
| SCHEMBL5734053 | 0.82 | GABRB3 (0.36) | RAPGEF4GABRB3NOTUMRIPK1CES2 | |
| SCHEMBL829381 | 0.82 | NOTUM (0.37) | RAPGEF4GABRB3NOTUMRIPK1CES2 | |
| SCHEMBL13170375 | 0.82 | RAPGEF4 (0.50) | RAPGEF4NOTUMRXRARXRBCES2 | |
| SCHEMBL13550151 | 0.81 | RAPGEF4 (0.38) | RAPGEF4GABRB3NOTUMRXRARXRB | |
| SCHEMBL21985725 | 0.80 | ALDH1A1 (0.34) | ALDH1A1CYP3A4HPGDALOX15TSHR | |
| SCHEMBL25798162 | 0.80 | GABRB3 (0.38) | RAPGEF4GABRB3NOTUMALDH1A1CYP3A4 | |
| SCHEMBL13550140 | 0.79 | GABRB3 (0.37) | RAPGEF4GABRB3NOTUMRXRARXRB | |
| SCHEMBL13550157 | 0.79 | GABRB3 (0.37) | RAPGEF4GABRB3NOTUMRXRARXRB | |
| SCHEMBL20974042 | 0.77 | TSHR (0.50) | RAPGEF4GABRB3NOTUMRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109912-A1 | 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-06-22 | — | — | WO | disclosed |
| US-8778929-B2 | Substituted heteroaryl inhibitors of B-RAF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-15 | — | — | US | disclosed |
| US-8653087-B2 | Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| US-20120094975-A1 | PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| US-20110312939-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-22 | — | — | US | disclosed |
| US-20100010058-A1 | Azoline Compounds for Combating Arthropod Pests | BASF SE (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20080312085-A1 | Pesticidal Compositions | BASF SE (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312085-A1 | Pesticidal Compositions | BASF SE (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007147701-A1 | AZOLINE COMPOUNDS FOR COMBATING ARTHROPOD PESTS | BASF SE (DE) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007071585-A1 | PESTCIDAL COMPOSITIONS | BASF SE (DE) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312939-A1 | NEW CHEMICAL COMPOUNDS | CCNA1, CCNT1, MKI67 | RAPGEF4 4563/4885GABRB3 3819/4885NOTUM 4461/4885 |
| US-20100010058-A1 | Azoline Compounds for Combating Arthropod Pests | NR0B1, NR4A1, NR4A3 | RAPGEF4 1810/4885GABRB3 2141/4885NOTUM 3331/4885 |
| US-20080312085-A1 | Pesticidal Compositions | ANXA1, PRDX1, PRDX2 | RAPGEF4 2837/4885GABRB3 2962/4885NOTUM 1459/4885 |
| US-20120094975-A1 | PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS | CCNT1, CCNA1, CCND1 | RAPGEF4 3591/4885GABRB3 4309/4885NOTUM 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.