Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656741 | 1.00 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL1009901 | 0.85 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL1009906 | 0.81 | MAOA (0.53) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL1009165 | 0.78 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL1011035 | 0.78 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL7993632 | 0.78 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL29405492 | 0.78 | MAOA (0.50) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL1010841 | 0.77 | PARP1 (0.46) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL625670 | 0.77 | MAOA (0.58) | MAOAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL19862022 | 0.76 | MAPK10 (0.46) | MAOAKDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417635-B | Pyrazolopyrimidines with anti-Respiratory Syncytial Virus (RSV) activity | 爱尔兰詹森科学公司 | 2024-01-02 | — | — | CN | disclosed |
| WO-2023029943-A1 | AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 星药科技(北京)有限公司 | 2023-03-09 | — | — | WO | disclosed |
| US-11339165-B2 | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2022-05-24 | — | — | US | disclosed |
| US-11339165-B2 | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2022-05-24 | — | — | US | disclosed |
| EP-3717486-B1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2022-03-23 | — | — | EP | disclosed |
| US-20200361942-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-19 | — | — | US | disclosed |
| US-20200361942-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-19 | — | — | US | disclosed |
| CN-111417635-A | Pyrazolopyrimidines having activity against Respiratory Syncytial Virus (RSV) | 爱尔兰詹森科学公司 | 2020-07-14 | — | — | CN | disclosed |
| CN-101501036-B | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO KGAA | 2013-04-17 | — | — | CN | disclosed |
| US-20110212956-A1 | Pyrazolopyrimidines for treating CNS disorders | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-09-01 | — | — | US | disclosed |
| US-5777132-A | CHEMICAL CONDENSATION OF NITRILE AMIDE WITH DIENOPHILE | AMERICAN CYANAMID COMPANY (US) | 1998-07-07 | — | — | US | disclosed |
| US-5777132-A | CHEMICAL CONDENSATION OF NITRILE AMIDE WITH DIENOPHILE | AMERICAN CYANAMID COMPANY (US) | 1998-07-07 | — | — | US | disclosed |
| US-5750726-A | INSECTICIDES; REACTION OF AMIDE NITRILE COMPOUND | AMERICAN CYANAMID COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5750726-A | INSECTICIDES; REACTION OF AMIDE NITRILE COMPOUND | AMERICAN CYANAMID COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5750726-A | INSECTICIDES; REACTION OF AMIDE NITRILE COMPOUND | AMERICAN CYANAMID COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| CN-1170718-A | Process for manufacture of 2-aryl-5-perfluoroalkylpyrrole derivatives and intermediates useful therefor | AMERICAN CYANAMID CO (US) | 1998-01-21 | — | — | CN | disclosed |
| CN-1170718-A | Process for manufacture of 2-aryl-5-perfluoroalkylpyrrole derivatives and intermediates useful therefor | AMERICAN CYANAMID CO (US) | 1998-01-21 | — | — | CN | disclosed |
| EP-0816337-A1 | A process for the manufacture of 2 aryl 5 perfluoroalkylpyrrole derivatives and intermediates useful therefor | American Cyanamid Company (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0816337-A1 | A process for the manufacture of 2 aryl 5 perfluoroalkylpyrrole derivatives and intermediates useful therefor | American Cyanamid Company (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0816337-A1 | A process for the manufacture of 2 aryl 5 perfluoroalkylpyrrole derivatives and intermediates useful therefor | American Cyanamid Company (US) | 1998-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361942-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | RRP15, MAVS, ACE | MAOA 2470/4885KDM4E 2862/4885ALDH1A1 1980/4885 |
| US-11339165-B2 | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) | RRP15, MAVS, ACE | MAOA 2470/4885KDM4E 2862/4885ALDH1A1 1980/4885 |
| US-20110212956-A1 | Pyrazolopyrimidines for treating CNS disorders | GRM5, GRM3, GRM1 | MAOA 3070/4885KDM4E 1101/4885ALDH1A1 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.