Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17167354 | 0.79 | MAOA (0.61) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL1010472 | 0.77 | MAOA (0.50) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL30656741 | 0.77 | MAOA (0.50) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL1009901 | 0.77 | MAOA (0.50) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL28739461 | 0.76 | MAOA (0.58) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL1148346 | 0.73 | MAOA (1.00) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL2616773 | 0.72 | MAOA (0.53) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL1009906 | 0.72 | MAOA (0.53) | MAOAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL4766558 | 0.72 | MAOA (0.53) | MAOAALDH1A1KDM4EGAAMAPT | |
| Hydrochloric Acid SCHEMBL10660329 | 0.72 | MAOA (0.96) | MAOAALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603217-B1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | MONTISERA LTD (FI) | 2015-04-08 | — | — | EP | claimed |
| US-8815898-B2 | 6,7-disubstituted-sioquinoline derivatives and their use | MONTISERA LTD (FI) | 2014-08-26 | — | — | US | claimed |
| EP-2603217-A1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | Montisera Ltd (FI) | 2013-06-19 | — | — | EP | claimed |
| US-20130137719-A1 | Novel 6,7-disubstituted-sioquinoline derivatives and their use | MONTISERA LTD (FI) | 2013-05-30 | — | — | US | claimed |
| WO-2012020170-A1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | Takio Ville (FI) | 2012-02-16 | — | — | WO | claimed |
| EP-2603217-B1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | MONTISERA LTD (FI) | 2015-04-08 | — | — | EP | disclosed |
| US-8815898-B2 | 6,7-disubstituted-sioquinoline derivatives and their use | MONTISERA LTD (FI) | 2014-08-26 | — | — | US | disclosed |
| EP-2603217-A1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | Montisera Ltd (FI) | 2013-06-19 | — | — | EP | disclosed |
| US-20130137719-A1 | Novel 6,7-disubstituted-sioquinoline derivatives and their use | MONTISERA LTD (FI) | 2013-05-30 | — | — | US | disclosed |
| WO-2012020170-A1 | NOVEL 6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES AND THEIR USE | Takio Ville (FI) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137719-A1 | Novel 6,7-disubstituted-sioquinoline derivatives and their use | OPRM1, OPRK1, SULT2A1 | MAOA 222/4885ALDH1A1 285/4885KDM4E 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.