Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PLEC | Q15149 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343373 | 0.83 | NEU3 (0.55) | HPGDALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL11662824 | 0.80 | HPGD (0.51) | HPGDALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL27894392 | 0.80 | HCAR3 (0.54) | HPGDALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL10105362 | 0.79 | CA12 (0.61) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL12074983 | 0.79 | HPGD (0.50) | HPGDALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL27894389 | 0.78 | ALDH1A1 (0.68) | HPGDALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL16533711 | 0.78 | GRM5 (0.53) | HPGDMEN1KMT2ACA2CA9 | |
| SCHEMBL2755400 | 0.77 | ALDH1A1 (0.56) | HPGDALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL22096845 | 0.75 | HPGD (0.46) | HPGDSMN1; SMN2KMT2AHTTCYP1A2 | |
| Hydrochloric Acid SCHEMBL10354232 | 0.75 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165520-A1 | PROCESS FOR THE SYNTHESIS OF PRODRUGS OF OPIOIDS | SHIRE LLC | 2012-06-28 | — | — | US | disclosed |
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE PHARMACEUTICALS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | OPRK1, OPRL1, OPRM1 | HPGD 94/4885ALDH1A1 225/4885SMN1; SMN2 1164/4885 |
| US-20120165520-A1 | PROCESS FOR THE SYNTHESIS OF PRODRUGS OF OPIOIDS | OPRM1, OPRK1, OPRD1 | HPGD 224/4885ALDH1A1 276/4885SMN1; SMN2 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.