Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 5/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 6/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TK1 | P04183 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123433 | 0.84 | ALB (0.53) | ALBNR1I2PDE4DADCY5 | |
| SCHEMBL8885064 | 0.82 | ALB (0.32) | ALBDNMT1ADRB1 | |
| SCHEMBL9220438 | 0.80 | ALB (0.40) | ALBDNMT1ADRB1LMNACACNA1F | |
| SCHEMBL28741406 | 0.78 | ALB (0.37) | ALBNR1I2PDE4DADCY5DNMT1 | |
| SCHEMBL15046170 | 0.77 | LMNA (0.50) | ALBNR1I2PDE4DADCY5DNMT1 | |
| SCHEMBL24839531 | 0.75 | TK1 (0.47) | ALBDNMT1ADRB1LMNAALDH1A1 | |
| SCHEMBL21275614 | 0.74 | AHCY (0.49) | ALBDNMT1ADRB1 | |
| SCHEMBL16629489 | 0.74 | AHCY (0.49) | ALBDNMT1ADRB1 | |
| SCHEMBL28741392 | 0.73 | ALB (0.36) | ALBNR1I2PDE4DADCY5 | |
| SCHEMBL20059119 | 0.73 | ALB (0.40) | ALBDNMT1ADRB1LMNACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861652-B2 | 2′ Fluoronucleosides | EMORY UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | EMORY UNIVERSITY | 2016-06-09 | — | — | US | disclosed |
| US-9180138-B2 | 2′-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | SCHINAZI RAYMOND F (US) | 2013-06-20 | — | — | US | disclosed |
| US-8168583-B2 | 2-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100173863-A1 | 2-Fluoronucleosides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-08 | — | — | US | disclosed |
| US-7662938-B2 | 2′-fluoronucleosides | EMORY UNIVERSITY (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080300398-A1 | 2'-FLUORONUCLEOSIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173863-A1 | 2-Fluoronucleosides | PNP, BCL3, NPC1 | ALB 2753/4885NR1I2 2587/4885PDE4D 2010/4885 |
| US-20080300398-A1 | 2'-FLUORONUCLEOSIDES | METTL3, BCL3, PNP | ALB 2185/4885NR1I2 2396/4885PDE4D 2333/4885 |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | PNP, BCL3, NPC1 | ALB 2635/4885NR1I2 2595/4885PDE4D 2039/4885 |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | PNP, BCL3, FUBP3 | ALB 2527/4885NR1I2 2669/4885PDE4D 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.