Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112662 | 0.84 | ALDH1A1 (0.38) | HPGDCHRNB4CHRNA3ALDH1A1SMN1; SMN2 | |
| SCHEMBL10122799 | 0.70 | CHRNB4 (0.39) | CHRNB4CHRNA3L3MBTL3 | |
| SCHEMBL3644854 | 0.70 | CHRM3 (0.51) | — | |
| SCHEMBL10112661 | 0.68 | SLC6A2 (0.44) | — | |
| SCHEMBL30017807 | 0.67 | CHRNB4 (0.41) | CHRNB4CHRNA3L3MBTL3 | |
| SCHEMBL30017341 | 0.67 | CHRNB4 (0.41) | CHRNB4CHRNA3L3MBTL3 | |
| SCHEMBL15995654 | 0.67 | CHRNB4 (0.41) | CHRNB4CHRNA3L3MBTL3 | |
| SCHEMBL2563607 | 0.66 | ALOX5 (0.46) | HPGDPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8487679 | 0.63 | TSHR (0.43) | HPGDPOLBALDH1A1LMNATSHR | |
| SCHEMBL31575348 | 0.62 | CHRNB2 (0.43) | HPGDCHRNB4CHRNA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135749-A2 | BIOMARKERS FOR PREDICTING SENSITIVITY TO CANCER TREATMENTS | GENENTECH, INC. (US) | 2012-10-04 | — | — | WO | disclosed |
| WO-2012088254-A1 | AUTOPHAGY INDUCER AND INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NEOPLASMS | GENENTECH, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |