Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DHPS | P49366 | 12/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700406 | 0.90 | LMNA (0.50) | LMNADHPSKMT2AMEN1POLB | |
| SCHEMBL625229 | 0.78 | CYP1A2 (0.44) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL1443043 | 0.76 | LMNA (0.44) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL13674052 | 0.75 | CYP1A2 (0.63) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL14483989 | 0.74 | KMT2A (0.56) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL29770374 | 0.73 | DHPS (0.58) | DHPS | |
| SCHEMBL618135 | 0.73 | DHPS (0.58) | DHPS | |
| SCHEMBL1011353 | 0.72 | LMNA (0.46) | LMNADHPSKMT2AMEN1POLB | |
| SCHEMBL2071241 | 0.70 | KMT2A (0.68) | LMNADHPSKMT2AMEN1POLB | |
| SCHEMBL1442223 | 0.70 | LMNA (0.67) | LMNAKMT2AMEN1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268634-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | Actavis Group PTC EHF (IS) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009112954-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | ACTAVIS GROUP PTC EHF (IS) | 2009-09-17 | — | — | WO | disclosed |