Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 9/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.44 |
| ▸ | TSHR | P16473 | 8/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.44 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011352 | 0.78 | LMNA (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL622958 | 0.75 | TSHR (0.45) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL13674052 | 0.72 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL34462910 | 0.69 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL3296809 | 0.69 | IDO1 (0.61) | ALDH1A1MAPTLMNAL3MBTL1IDO1 | |
| SCHEMBL7700406 | 0.68 | LMNA (0.50) | CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL1443043 | 0.67 | LMNA (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL1748845 | 0.66 | ALDH1A1 (0.53) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL6754661 | 0.66 | IDO1 (0.52) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL4464149 | 0.66 | DHFR (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603497-B1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA P LTD (IN) | 2018-08-08 | — | — | EP | disclosed |
| US-9139537-B2 | Process for preparation of bosentan | MEGAFINE PHARMA(P) LTD. (IN) | 2015-09-22 | — | — | US | disclosed |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | MEGAFINE PHARMA (P) LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| WO-2013136110-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | NATCO PHARMA LIMITED (IN) | 2013-09-19 | — | — | WO | disclosed |
| US-20130245259-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | NATCO PHARMA LIMITED (IN) | 2013-09-19 | — | — | US | disclosed |
| EP-2603497-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | Megafine Pharma (P) Ltd. (IN) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020421-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA (P) LTD. (IN) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245259-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | VASP, EDNRB, PTGIR | CYP1A2 211/4885CYP3A4 51/4885CYP2D6 233/4885 |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | BMP6, EDNRB, PAH | CYP1A2 1617/4885CYP3A4 629/4885CYP2D6 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.