Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 13/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700406 | 0.78 | LMNA (0.50) | LMNAL3MBTL1ALDH1A1HTTDHPS | |
| SCHEMBL1011352 | 0.72 | LMNA (0.44) | LMNAL3MBTL1ALDH1A1DHPSMEN1 | |
| SCHEMBL11544969 | 0.72 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1MAPK1HTTDHPS | |
| SCHEMBL618135 | 0.72 | DHPS (0.58) | DHPS | |
| SCHEMBL29770374 | 0.72 | DHPS (0.58) | DHPS | |
| SCHEMBL9423908 | 0.69 | LMNA (0.55) | LMNAL3MBTL1ALDH1A1DHPSMEN1 | |
| SCHEMBL3236824 | 0.69 | METAP1 (0.34) | LMNAL3MBTL1ALDH1A1POLB | |
| SCHEMBL1443043 | 0.68 | LMNA (0.44) | LMNAL3MBTL1ALDH1A1HTTMEN1 | |
| SCHEMBL190585 | 0.68 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1MAPK1HTT | |
| SCHEMBL16507366 | 0.68 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1MAPK1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268634-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | Actavis Group PTC EHF (IS) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009112954-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | ACTAVIS GROUP PTC EHF (IS) | 2009-09-17 | — | — | WO | disclosed |