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SCHEMBL10115769

SCHEMBL10115769

CC(C)(C)S(=O)(=O)NC1CCN(C(=O)Nc2ccc(-c3ccco3)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPY5R Q15761 1/20 0.51
▸ TDP1 Q9NUW8 4/20 0.47
▸ PTPN7 P35236 4/20 0.47
▸ NPSR1 Q6W5P4 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ TAAR1 Q96RJ0 3/20 0.45
▸ KMT2A Q03164 3/20 0.43
▸ L3MBTL1 Q9Y468 3/20 0.43
▸ RHOA P61586 1/20 0.42
▸ GPR119 Q8TDV5 1/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ POLB P06746 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ THRB P10828 2/20 0.42
▸ HPGD P15428 2/20 0.42
▸ ALOX15 P16050 2/20 0.42
▸ MAPK1 P28482 2/20 0.42
▸ CASP1 P29466 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10115825 0.89 KMT2A (0.50) NPY5RTDP1PTPN7NPSR1LMNA
SCHEMBL10116116 0.86 NPY5R (0.51) NPY5RTDP1PTPN7NPSR1LMNA
SCHEMBL10115657 0.85 LMNA (0.50) NPY5RNPSR1LMNAKMT2AKDM4E
SCHEMBL10115805 0.84 IMPDH2 (0.49) NPSR1LMNAKMT2AGPR119KDM4E
SCHEMBL14424256 0.83 NPY5R (0.48) NPY5RTAAR1KMT2ARHOAKDM4E
SCHEMBL10114560 0.83 NPY5R (0.48) NPY5RTAAR1KMT2ARHOAKDM4E
SCHEMBL10115773 0.83 LMNA (0.44) NPY5RNPSR1LMNAKMT2AL3MBTL1
SCHEMBL10115579 0.82 ALDH1A1 (0.55) TDP1NPSR1LMNAKDM4EALDH1A1
SCHEMBL10115780 0.82 FAAH (0.49) NPSR1LMNACCR8
SCHEMBL10115527 0.81 LMNA (0.66) TDP1NPSR1LMNAKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R NPY5R 1/4885TDP1 4408/4885PTPN7 102/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R NPY5R 1/4885TDP1 4084/4885PTPN7 113/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R NPY5R 1/4885TDP1 4424/4885PTPN7 105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.