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SCHEMBL10115780

SCHEMBL10115780

CC(C)(C)S(=O)(=O)NC1CCN(C(=O)Nc2ccc(-c3ncco3)cc2)CC1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 1/20 0.49
▸ EPHX2 P34913 1/20 0.49
▸ LMNA P02545 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ LTA4H P09960 7/20 0.43
▸ BTK Q06187 2/20 0.40
▸ TRPV1 Q8NER1 2/20 0.39
▸ TRPA1 O75762 1/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ TRPM8 Q7Z2W7 1/20 0.39
▸ KIF18A Q8NI77 1/20 0.38
▸ CA2 P00918 2/20 0.38
▸ CA9 Q16790 2/20 0.38
▸ CCR8 P51685 1/20 0.38
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10116125 0.86 FAAH (0.47) FAAHEPHX2LMNANPSR1LTA4H
SCHEMBL10115817 0.86 RAB9A (0.39) FAAHEPHX2LMNANPSR1LTA4H
SCHEMBL10115769 0.82 NPY5R (0.51) LMNANPSR1CCR8
SCHEMBL10115773 0.81 LMNA (0.44) EPHX2LMNANPSR1TRPV1CA2
SCHEMBL10115657 0.81 LMNA (0.50) FAAHEPHX2LMNANPSR1TRPV1
SCHEMBL10115805 0.80 IMPDH2 (0.49) LMNANPSR1
SCHEMBL10115527 0.80 LMNA (0.66) FAAHLMNANPSR1
SCHEMBL12882021 0.80 LMNA (0.53) EPHX2LMNANPSR1CA2CA9
SCHEMBL10115617 0.80 LMNA (0.53) EPHX2LMNANPSR1CA2CA9
SCHEMBL10115581 0.79 CNR2 (0.56) EPHX2LMNANPSR1TRPV1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R FAAH 974/4885EPHX2 2158/4885LMNA 1925/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R FAAH 994/4885EPHX2 2527/4885LMNA 2068/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R FAAH 974/4885EPHX2 2306/4885LMNA 1857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.