Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10117508 | 0.87 | NPC1 (0.41) | NR1H2NPC1RAB9AFPR2 | |
| SCHEMBL10117537 | 0.85 | RAB9A (0.49) | NR1H2NPC1RAB9AKDM4EHDAC8 | |
| SCHEMBL10117536 | 0.85 | MTOR (0.38) | NR1H2 | |
| SCHEMBL10117510 | 0.82 | MEN1 (0.45) | NR1H2NPC1RAB9AFPR2 | |
| SCHEMBL10117881 | 0.81 | MAPK1 (0.43) | MAPT | |
| SCHEMBL10117499 | 0.80 | FPR2 (0.39) | NR1H2NPC1RAB9AFPR2 | |
| SCHEMBL13655228 | 0.76 | KMT2A (0.42) | NR1H2NR1H3 | |
| SCHEMBL13663124 | 0.76 | CNR2 (0.42) | NR1H2NR1H3 | |
| SCHEMBL4062421 | 0.72 | EGLN2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL10117534 | 0.71 | NR1H2 (0.40) | NR1H2ROCK2NR1H3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087976-A2 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-06-28 | — | — | WO | disclosed |