Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845929 | 0.88 | GAA (0.48) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL845285 | 0.87 | GAA (0.48) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL10119511 | 0.82 | GAA (0.44) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL844996 | 0.82 | CYP2C9 (0.50) | GAALMNAPABPC1CYP2C9CYP2C19 | |
| SCHEMBL871645 | 0.81 | PABPC1 (0.43) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL873858 | 0.81 | GAA (0.42) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL845131 | 0.80 | PABPC1 (0.49) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL845007 | 0.80 | PABPC1 (0.49) | GAALMNAKDM4EPABPC1CYP2C9 | |
| SCHEMBL845008 | 0.75 | ALDH1A1 (0.54) | LMNACYP2C9CYP2C19MAPK1ALDH1A1 | |
| SCHEMBL845312 | 0.75 | GAA (0.60) | GAALMNAKDM4EPABPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |