SCHEMBL1011986

SCHEMBL1011986

CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 7/20 0.73
EPHA2 P29317 3/20 0.73
HSD17B10 Q99714 3/20 0.73
TDP1 Q9NUW8 3/20 0.73
AKR1B10 O60218 2/20 0.73
AKR1B1 P15121 2/20 0.73
LMNA P02545 2/20 0.73
EFNA1 P20827 1/20 0.73
PSEN1 P49768 1/20 0.73
PSEN2 P49810 1/20 0.73
APH1B Q8WW43 1/20 0.73
NCSTN Q92542 1/20 0.73
APH1A Q96BI3 1/20 0.73
PSENEN Q9NZ42 1/20 0.73
MEN1 O00255 1/20 0.73
KMT2A Q03164 1/20 0.73
CYP2D6 P10635 1/20 0.55
CYP2C19 P33261 1/20 0.55
INPP5D Q92835 1/20 0.54
CASP7 P55210 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19313992 1.00 GPBAR1 (0.73) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL1011985 1.00 GPBAR1 (0.73) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL27276852 1.00 GPBAR1 (0.73) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL14812914 1.00 GPBAR1 (0.73) GPBAR1EPHA2HSD17B10TDP1AKR1B10
Alcohol SCHEMBL10569059 0.96 GPBAR1 (0.72) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL7705524 0.94 GPBAR1 (0.69) GPBAR1EPHA2HSD17B10TDP1AKR1B10
Sulfuric Acid SCHEMBL3905020 0.93 GPBAR1 (0.71) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL7708084 0.93 GPBAR1 (0.70) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL27498874 0.93 GPBAR1 (0.70) GPBAR1EPHA2HSD17B10TDP1AKR1B10
SCHEMBL30128543 0.91 GPBAR1 (0.69) GPBAR1EPHA2HSD17B10TDP1AKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1027 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12601000-B2 Method for the hydroxylation of steroids ANNIKKI GMBH (AT) 2026-04-14 US claimed
EP-4238966-B1 TETRAHYDRONAPHTHALENE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN) 2026-03-11 EP claimed
US-12497378-B2 Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) 2025-12-16 US claimed
US-12350381-B2 Nanoparticles containing cellular membrane and uses thereof ARYTHA BIOSCIENCES, LLC (US) 2025-07-08 US claimed
CN-114206360-B Nanoparticle containing cell membrane and use thereof 阿瑞萨生物科技有限责任公司 2024-11-22 CN claimed
US-20240209410-A1 METHOD FOR THE HYDROXYLATION OF STEROIDS PHARMAZELL GMBH (DE) 2024-06-27 US claimed
WO-2023247952-A1 CRYSTALLINE PHARMACEUTICAL COMPOSITION FOR INHALATION COMPRISING SUGAR AND LIPID COMPOSITE PARTICLES AND PROCESS FOR MANUFACTURE HOVIONE SCIENTIA LIMITED (IE) 2023-12-28 WO claimed
EP-3674289-B9 LONG-ACTING RASAGILINE PRODRUG, PREPARATION METHOD AND USE THEREOF GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN) 2023-12-13 EP claimed
US-20230391744-A1 TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. (CN) 2023-12-07 US claimed
US-20230365995-A1 LIPID NANOPARTICLE COMPOSITIONS PRECISION BIOSCIENCES, INC. (US) 2023-11-16 US claimed
CN-1138585-A Mixed micelles HOFFMANN LA ROCHE (CH) 1996-12-25 CN claimed
US-5508275-A CARDIOVASCULAR DISORDERS, ANTIINFLAMMATORY AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-16 US claimed
WO-1996004296-A1 PREGNANES AND CHOLANES AS NEUROCHEMICAL INITIATORS OF CHANGE IN HYPOTHALAMIC FUNCTION PHERIN CORPORATION (US) 1996-02-15 WO claimed
CN-1107041-A Transmucosal delivery of macromolecular drugs THERA TECH INC (US) 1995-08-23 CN claimed
EP-0665894-A1 CULTURE MEDIUM FOR THE IDENTIFICATION OF SALMONELLA AND PROCESS FOR ITS USE Rambach, Alain (FR) 1995-08-09 EP claimed
US-5318987-A Used for prophylaxis and treats coronary, circulatory and vascular diseases HOECHST AKTIENGESELLSCHAFT (DE) 1994-06-07 US claimed
WO-1994009152-A1 CULTURE MEDIUM FOR THE IDENTIFICATION OF SALMONELLA AND PROCESS FOR ITS USE MERCK PATENT GMBH (DE) 1994-04-28 WO claimed
US-4987023-A Organic thin-film device KABUSHIKI KAISHA TOSHIBA (JP) 1991-01-22 US claimed
US-4460509-A STEROIDS WITH HETERO RING SIDE CHAIN BETH ISRAEL MEDICAL CENTER (US) 1984-07-17 US claimed
US-3998859-A Introducing Δ11 unsaturation into steroid compounds EASTMAN KODAK COMPANY (US) 1976-12-21 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230391744-A1 TETRAHYDRONAPHTHALENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF CYP11B2, HTT, REN GPBAR1 1029/4885EPHA2 4492/4885HSD17B10 263/4885
US-12601000-B2 Method for the hydroxylation of steroids CYP11B1, CYP11B2, CYP11A1 GPBAR1 312/4885EPHA2 1558/4885HSD17B10 54/4885
US-12497378-B2 Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof CYP11B2, HTT, REN GPBAR1 1029/4885EPHA2 4492/4885HSD17B10 263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.