Sugi Predict

Sugi Predict / Compounds / SCHEMBL1012052

SCHEMBL1012052

SCHEMBL1012052

CC(C)CC1NC(=O)NC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.43
▸ ADAMTS5 Q9UNA0 3/20 0.42
▸ MMP2 P08253 2/20 0.42
▸ ADAM17 P78536 1/20 0.42
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ GAA P10253 5/20 0.37
▸ HTT P42858 1/20 0.37
▸ PAX8 Q06710 1/20 0.37
▸ PTGER3 P43115 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.34
▸ BACE1 P56817 1/20 0.34
▸ MMP14 P50281 1/20 0.34
▸ THRA P10827 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ SLC18A2 Q05940 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29067975 1.00 TSHR (0.43) TSHRADAMTS5MMP2ADAM17MEN1
SCHEMBL29598045 1.00 TSHR (0.43) TSHRADAMTS5MMP2ADAM17MEN1
SCHEMBL29161773 0.83 ADAMTS5 (0.40) TSHRADAMTS5MMP2ADAM17MEN1
SCHEMBL41056 0.83 ADAMTS5 (0.40) TSHRADAMTS5MMP2ADAM17MEN1
SCHEMBL163425 0.81 MEN1 (0.41) MEN1KMT2AGAAHTTPAX8
SCHEMBL2867325 0.81 MEN1 (0.41) MEN1KMT2AGAAHTTPAX8
D-Leucine SCHEMBL11435084 0.81 SLC7A5 (0.51) TSHRADAMTS5MMP2ADAM17GAA
Leucine SCHEMBL11083186 0.81 SLC7A5 (0.51) TSHRADAMTS5MMP2ADAM17GAA
Leucine SCHEMBL11083182 0.81 SLC7A5 (0.51) TSHRADAMTS5MMP2ADAM17GAA
SCHEMBL13167432 0.79 MEN1 (0.38) MEN1KMT2AGAAHTTPAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119899101-A Green synthesis method of alpha-ketoleucine calcium and intermediate thereof 河北天成药业股份有限公司 2025-04-29 — — CN claimed
CN-113735776-B Preparation method of alpha-ketoleucine calcium and intermediate thereof 北京福元医药股份有限公司沧州分公司 2023-09-15 — — CN claimed
CN-109468304-B Hydantoinase mutants 赢创运营有限公司 2022-04-19 — — CN claimed
US-9957536-B2 Mutants of hydantoinase EVONIK TECHNOCHEMIE GMBH (DE) 2018-05-01 — — US claimed
EP-2780451-B1 MUTANTS OF HYDANTOINASE EVONIK TECHNOCHEMIE GMBH (DE) 2017-09-20 — — EP claimed
US-20150056667-A1 MUTANTS OF HYDANTOINASE EVONIK OPERATIONS GMBH (DE) 2015-02-26 — — US claimed
EP-2780451-A1 MUTANTS OF HYDANTOINASE Evonik Industries AG (DE) 2014-09-24 — — EP claimed
WO-2013072486-A1 MUTANTS OF HYDANTOINASE EVONIK INDUSTRIES AG (DE) 2013-05-23 — — WO claimed
US-7582454-B2 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids AJINOMOTO CO. INC. (JP) 2009-09-01 — — US claimed
US-20060246553-A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids AJINOMOTO CO., INC. (JP) 2006-11-02 — — US claimed
US-7112431-B2 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids AJINOMOTO CO. INC. (JP) 2006-09-26 — — US claimed
US-20050112729-A1 Recombinant DNA having hydantoinase gene and carbamylase gene and process for producing amino acid AJINOMOTO CO., INC. (JP) 2005-05-26 — — US claimed
US-20050084946-A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids AJINOMOTO CO., INC. (JP) 2005-04-21 — — US claimed
US-20020102713-A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids AJINOMOTO CO., INC. (JP) 2002-08-01 — — US claimed
EP-0739978-A2 Hydantoinase from agrobacterium tumefaciens and its use for the preparation of optically pure N-carbamyl-D-amino acids from racemic hydantoins W.R. Grace & Co.-Conn. (US) 1996-10-30 — — EP claimed
US-5338859-A Reacting a hydantoin with a calcium base; crystallization; precipitation; separation HOECHST CELANESE CORPORATION (US) 1994-08-16 — — US claimed
US-5071752-A Contacting nocardia or its enzymes with a dl-imidazolidinedione derivative; immobilization SCHERING AKTIENGESELLSCHAFT (DE) 1991-12-10 — — US claimed
US-4436910-A SAPONIFICATION DEGUSSA AKTIENGESELLSCHAFT (DE) 1984-03-13 — — US claimed
EP-4608574-A1 PROCESSES FOR REDUCING ENVIRONMENTAL AVAILABILITY OF ENVIRONMENTAL POLLUTANTS ALBEMARLE CORPORATION (US) 2025-09-03 — — EP disclosed
US-4311181-A Ambient temperature application of indicia to elastomer substrates THE FIRESTONE TIRE & RUBBER COMPANY (US) 1982-01-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050084946-A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids HDHD5, HAAO, MTAP TSHR 4606/4885ADAMTS5 1865/4885MMP2 737/4885
US-20020102713-A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids HDHD5, HAAO, MTAP TSHR 4606/4885ADAMTS5 1865/4885MMP2 737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.