Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | OGT | O15294 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695207 | 0.89 | KMO (0.51) | POLBMEN1CYP1A2CYP2D6MAPT | |
| SCHEMBL10120527 | 0.89 | ABCG2 (0.46) | KDM4EMEN1KMT2ABCHEABCG2 | |
| SCHEMBL1694845 | 0.82 | KDM4E (0.51) | POLBKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL1694435 | 0.77 | OGT (0.45) | NOTUMKDM4EABCG2DHODHOGT | |
| SCHEMBL1694971 | 0.76 | LDHA (0.53) | KDM4EBCHEKMOABCG2DHODH | |
| SCHEMBL15100599 | 0.74 | DHODH (0.47) | POLBKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL3281879 | 0.72 | KDM4E (0.60) | POLBKDM4EMEN1MAPTKMT2A | |
| SCHEMBL21044565 | 0.72 | OGT (0.53) | NOTUMKDM4EABCG2OGT | |
| SCHEMBL15100471 | 0.70 | PRSS12 (0.47) | POLBKMODHODHCDC7OGT | |
| SCHEMBL1939020 | 0.70 | KMO (0.72) | NOTUMKDM4EMAPTKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006068-A2 | COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-12 | — | — | WO | disclosed |