Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123178 | 0.83 | NOS3 (0.36) | OPRM1SIGMAR1OPRD1CYP19A1CYP11B1 | |
| SCHEMBL10123012 | 0.83 | OPRM1 (0.35) | OPRM1SIGMAR1OPRD1CYP19A1CYP11B1 | |
| SCHEMBL10123013 | 0.79 | SIGMAR1 (0.32) | OPRM1SIGMAR1OPRD1HTR2CHTR2B | |
| SCHEMBL10123214 | 0.79 | LMNA (0.35) | OPRM1SIGMAR1OPRD1HTR2CHTR2B | |
| SCHEMBL10123200 | 0.75 | LMNA (0.36) | CYP19A1CHRNA7 | |
| SCHEMBL10123203 | 0.74 | — | — | |
| SCHEMBL10108928 | 0.73 | KDM1A (0.40) | OPRM1SIGMAR1CYP19A1CYP11B1 | |
| SCHEMBL318614 | 0.73 | KDM1A (0.40) | OPRM1SIGMAR1CYP19A1CYP11B1 | |
| SCHEMBL10123024 | 0.68 | CHRNA7 (0.33) | CHRNA7 | |
| SCHEMBL10123195 | 0.65 | HSD11B1 (0.33) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093302-B2 | Substituted tetralins as selective estrogen receptor-β agonists | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100249075-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249075-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ESR2, ERLIN1, ESRRG | OPRM1 158/4885SIGMAR1 380/4885OPRD1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.