Sugi Predict

Sugi Predict / Compounds / SCHEMBL10124296

SCHEMBL10124296

SCHEMBL10124296

CC(O)c1ncccc1Br

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 1/20 0.40
▸ SMN1; SMN2 Q16637 4/20 0.35
▸ MEN1 O00255 3/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ HSP90AA1 P07900 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ PDK2 Q15119 1/20 0.35
▸ AXL P30530 1/20 0.33
▸ DYRK1A Q13627 1/20 0.32
▸ ALDH1A1 P00352 4/20 0.32
▸ APAF1 O14727 1/20 0.32
▸ TDP2 O95551 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ CASP3 P42574 1/20 0.32
▸ SENP8 Q96LD8 1/20 0.32
▸ SENP7 Q9BQF6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29808658 1.00 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL28825229 1.00 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL23295658 1.00 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL30674901 1.00 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL31068984 0.85 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL2627815 0.85 TRPM8 (0.40) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL26271641 0.79 TRPM8 (0.37) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL27140480 0.79 TRPM8 (0.37) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL23006312 0.79 TRPM8 (0.37) TRPM8SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL29857523 0.77 NOS3 (0.45) SMN1; SMN2KDM4EHSP90AA1HTTPDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117625565-A Preparation method of (S) -3-bromo-2- (1-methoxyethyl) pyridine 上海锐康生物技术研发有限公司 2024-03-01 — — CN claimed
WO-2026106912-A1 RAS INHIBITORS Revolution Medicines, Inc. (US) 2026-05-21 — — WO disclosed
US-12624053-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2026-05-12 — — US disclosed
US-20260103454-A1 MODULATORS OF HEMOGLOBIN GLOBAL BLOOD THERAPEUTICS INC (US) 2026-04-16 — — US disclosed
US-20260070930-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2026-03-12 — — US disclosed
EP-4696316-A2 RAS INHIBITORS Revolution Medicines, Inc. (US) 2026-02-18 — — EP disclosed
US-20260042740-A1 RAS INHIBITORS REVOLUTION MEDICINES INC (US) 2026-02-12 — — US disclosed
EP-4054719-B1 RAS INHIBITORS REVOLUTION MEDICINES INC (US) 2026-02-11 — — EP disclosed
US-20250388598-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-12-25 — — US disclosed
US-20250388608-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-12-25 — — US disclosed
US-10683285-B2 Modulators of hemoglobin GLOBAL BLOOD THERAPEUTICS, INC. (US) 2020-06-16 — — US disclosed
US-20200157085-A1 MODULATORS OF HEMOGLOBIN GLOBAL BLOOD THERAPEUTICS, INC. 2020-05-21 — — US disclosed
EP-2655371-B1 PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INT (DE) 2015-02-25 — — EP disclosed
CN-104313075-A Cell production method for photoactive bromopyridyl ethanol UNIV QINGDAO SCIENCE & TECHNOLOGY 2015-01-28 — — CN disclosed
CN-104313075-A Cell production method for photoactive bromopyridyl ethanol UNIV QINGDAO SCIENCE & TECHNOLOGY 2015-01-28 — — CN disclosed
US-8546442-B2 Pyrazolopiperidine compounds as CCR1 receptor antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-10-01 — — US disclosed
US-8546442-B2 Pyrazolopiperidine compounds as CCR1 receptor antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-10-01 — — US disclosed
US-20120322790-A1 Pyrazolopiperidine Compounds As CCR1 Receptor Antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-20 — — US disclosed
US-20120322790-A1 Pyrazolopiperidine Compounds As CCR1 Receptor Antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-20 — — US disclosed
WO-2012087782-A1 PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070930-A1 RAS INHIBITORS KRAS, NRAS, RIN1 TRPM8 4562/4885SMN1; SMN2 4241/4885MEN1 402/4885
US-20200157085-A1 MODULATORS OF HEMOGLOBIN HBG1, HBG2, HBB TRPM8 2686/4885SMN1; SMN2 1769/4885MEN1 4098/4885
US-10683285-B2 Modulators of hemoglobin HBG1, HBG2, HBB TRPM8 2686/4885SMN1; SMN2 1769/4885MEN1 4098/4885
US-20260042740-A1 RAS INHIBITORS KRAS, NRAS, HRAS TRPM8 4684/4885SMN1; SMN2 3810/4885MEN1 2432/4885
US-12624053-B2 Ras inhibitors KRAS, NRAS, HMGCR TRPM8 3852/4885SMN1; SMN2 4495/4885MEN1 573/4885
US-20120322790-A1 Pyrazolopiperidine Compounds As CCR1 Receptor Antagonists CCR1, CCR3, CCR4 TRPM8 755/4885SMN1; SMN2 1559/4885MEN1 3429/4885
US-20260103454-A1 MODULATORS OF HEMOGLOBIN HBZ, HBB, HBG2 TRPM8 2707/4885SMN1; SMN2 1425/4885MEN1 1784/4885
US-20250388608-A1 RAS INHIBITORS KRAS, NRAS, HMGCR TRPM8 3852/4885SMN1; SMN2 4495/4885MEN1 573/4885
US-20250388598-A1 RAS INHIBITORS KRAS, NRAS, G3BP2 TRPM8 4013/4885SMN1; SMN2 4394/4885MEN1 1044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.