Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724907 | 0.84 | PIK3CA (0.45) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL725321 | 0.81 | GAA (0.47) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL20489644 | 0.69 | TRPM8 (0.33) | MAPTKMT2A | |
| SCHEMBL724741 | 0.69 | CTSK (0.45) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL3140235 | 0.69 | ALOX15 (0.47) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL3083538 | 0.64 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL15348889 | 0.64 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL2340680 | 0.63 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL12752822 | 0.62 | ALDH1A1 (0.50) | PIK3CDPIK3CAPIK3CBALDH1A1SMN1; SMN2 | |
| SCHEMBL8553674 | 0.62 | P2RY1 (0.37) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410095-B2 | Thiazolopyrimidinone derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120053147-A1 | THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053147-A1 | THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CA 2/4885PIK3CB 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.