Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29101911 | 0.86 | TAAR1 (0.44) | DRD4TAAR1SIGMAR1SMN1; SMN2GRIN2B | |
| SCHEMBL10108244 | 0.85 | ALDH1A1 (0.49) | DRD4TAAR1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18129124 | 0.81 | FPR2 (0.49) | DRD4HTTALDH1A1KDM4E | |
| SCHEMBL1239334 | 0.80 | TAAR1 (0.53) | TAAR1SIGMAR1ALDH1A1GRIN2B | |
| SCHEMBL19994655 | 0.78 | FAAH (0.45) | HTTALDH1A1SMN1; SMN2GRIN2B | |
| SCHEMBL2553251 | 0.77 | TAAR1 (0.57) | TAAR1SMN1; SMN2GRIN2BKDM4ETDP1 | |
| SCHEMBL9471338 | 0.76 | DRD4 (0.62) | DRD4TAAR1HTTALDH1A1GRIN2B | |
| SCHEMBL28206562 | 0.75 | CCR5 (0.49) | HTTALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL17748901 | 0.75 | CCR3 (0.53) | — | |
| SCHEMBL17506476 | 0.75 | DRD4 (0.42) | DRD4TAAR1SIGMAR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082805-A1 | SUBSTITUTED AMINO TRIAZOLES, AND METHODS USING SAME | The Institute For Drug Delivery (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015095701-A1 | SUBSTITUTED AMINO TRIAZOLES, AND METHODS USING SAME | THE INSTITUTE FOR DRUG DELIVERY (US) | 2015-06-25 | — | — | WO | disclosed |
| US-8110574-B2 | Derivatives of 4-aminopiperidine and their use as a medicament | IPSEN PHARMA S.A.S. (FR) | 2012-02-07 | — | — | US | disclosed |
| US-20110312963-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD (GB) | 2011-12-22 | — | — | US | disclosed |
| US-20110059971-A1 | DERIVATIVES OF 4-AMINOPIPERIDINE AND THEIR USE AS A MEDICAMENT | IPSEN S.A.S. (FR) | 2011-03-10 | — | — | US | disclosed |
| US-7858789-B2 | Derivatives of 4-aminopiperidine and their use as a medicament | IPSEN PHARMA S.A.S. (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20090149652-A1 | Derivatives of 4-aminopiperidine and their use as a medicament | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES | 2009-06-11 | — | — | US | disclosed |
| EP-1286966-B1 | 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINE | SOD CONSEILS RECH APPLIC (FR) | 2008-07-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149652-A1 | Derivatives of 4-aminopiperidine and their use as a medicament | SSTR4, SSTR3, SSTR1 | DRD4 82/4885TAAR1 32/4885SIGMAR1 136/4885 |
| US-20110312963-A1 | P38 MAP KINASE INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | DRD4 4829/4885TAAR1 2971/4885SIGMAR1 1388/4885 |
| US-20110059971-A1 | DERIVATIVES OF 4-AMINOPIPERIDINE AND THEIR USE AS A MEDICAMENT | SSTR4, SSTR3, SSTR1 | DRD4 82/4885TAAR1 32/4885SIGMAR1 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.