Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876773 | 0.83 | LRRK2 (0.47) | LRRK2ROCK2ROCK1CYP11B1CYP11B2 | |
| SCHEMBL441242 | 0.81 | LRRK2 (0.47) | LRRK2ROCK2ROCK1MEN1ALDH1A1 | |
| SCHEMBL3755666 | 0.80 | NOS1 (0.69) | LRRK2NOS1ATRATRIPGAK | |
| SCHEMBL30414390 | 0.78 | CYP11B1 (0.53) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 | |
| SCHEMBL11992447 | 0.72 | TGFBR1 (0.51) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 | |
| SCHEMBL13473249 | 0.71 | LRRK2 (0.55) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 | |
| SCHEMBL14376028 | 0.70 | ALDH1A1 (0.45) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 | |
| SCHEMBL13354353 | 0.70 | CYP11B2 (0.63) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 | |
| SCHEMBL19406806 | 0.69 | HCRTR1 (0.41) | LRRK2CYP11B1CYP11B2ALDH1A1ATR | |
| SCHEMBL13778343 | 0.69 | NOS3 (0.52) | LRRK2CYP11B1CYP11B2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065205-A1 | PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065205-A1 | PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY5R | LRRK2 1099/4885ROCK2 3021/4885ROCK1 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.