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SCHEMBL10134245

SCHEMBL10134245

Cc1ccc2c(c1)C(C)(C)c1cc(O)c3cc(C)ccc3c1-2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ SENP6 Q9GZR1 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ TRPA1 O75762 2/20 0.33
▸ TP53 P04637 2/20 0.32
▸ LCK P06239 1/20 0.32
▸ CNR2 P34972 2/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ TRPV1 Q8NER1 1/20 0.32
▸ TRPV3 Q8NET8 1/20 0.32
▸ TRPV4 Q9HBA0 1/20 0.32
▸ TRPV2 Q9Y5S1 1/20 0.32
▸ CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2630542 0.89 RAB9A (0.40) PDK2TDP1CASP3RAB9AATM
SCHEMBL26032670 0.88 MAPT (0.37) TDP1CASP3RAB9ASENP8SENP7
SCHEMBL1813048 0.86 PDK2 (0.38) PDK2TDP1CASP3RAB9AATM
SCHEMBL29664007 0.84 CSNK2A2 (0.34) PDK2TDP1CASP3RAB9AATM
SCHEMBL1962962 0.84 CSNK2A2 (0.34) PDK2TDP1CASP3RAB9AATM
SCHEMBL1962765 0.81 CSNK2A2 (0.40) TDP1CASP3RAB9AATMNPSR1
SCHEMBL29664192 0.81 CSNK2A2 (0.40) TDP1CASP3RAB9AATMNPSR1
SCHEMBL24604943 0.80 PDK2 (0.32) PDK2
SCHEMBL3147109 0.80 ALK (0.38) PDK2TDP1CA1CA2HSD17B10
SCHEMBL1815176 0.80 PGR (0.34) PDK2CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND TOKUYAMA CORPORATION (JP) 2023-08-03 — — US disclosed
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND TOKUYAMA CORPORATION (JP) 2023-08-03 — — US disclosed
CN-113943267-A Method for synthesizing naphthopyran photochromic dye by using microchannel reactor 广州盛色科技有限公司 2022-01-18 — — CN disclosed
US-8277699-B2 Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans Transistions Optical, Inc. (US) 2012-10-02 — — US disclosed
US-20120053341-A1 PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2012-03-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053341-A1 PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS MITF, NPEPPS, GNE PDK2 4268/4885TDP1 2451/4885CASP3 3521/4885
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND RB1, CRY2, CDK16 PDK2 1930/4885TDP1 2783/4885CASP3 1477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.