Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.89 |
| ▸ | PPIA | P62937 | 5/20 | 0.89 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.89 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.89 |
| ▸ | FKBP1B | P68106 | 2/20 | 0.89 |
| ▸ | PPP3CA | Q08209 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.89 |
| ▸ | NPC1 | O15118 | 1/20 | 0.89 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.89 |
| ▸ | GMNN | O75496 | 1/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.89 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | POLB | P06746 | 1/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 1/20 | 0.89 |
| ▸ | RARB | P10826 | 1/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.89 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708943 | 1.00 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL18163232 | 1.00 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL16596082 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL22033395 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL102191 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL19646863 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL439348 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL22032784 | 0.98 | ABCB1 (0.89) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| SCHEMBL23110210 | 0.94 | ABCB1 (1.00) | ABCB1PPIAABCC1ABCC2FKBP1B | |
| Cyclosporine SCHEMBL24239036 | 0.94 | ABCB1 (1.00) | ABCB1PPIAABCC1ABCC2FKBP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 800 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250339520-A1 | COMPOSITIONS AND METHODS FOR USE IN KRAS-TARGETED THERAPIES FOR THE TREATMENT OF CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2025-11-06 | — | — | US | claimed |
| US-12201669-B2 | Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-01-21 | — | — | US | claimed |
| CN-115266996-B | Analysis method and application of related substances in cyclosporine A preparation | 兆科（广州）眼科药物有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-115266996-A | Analysis method and application of related substances in cyclosporin A preparation | 兆科（广州）眼科药物有限公司 | 2022-11-01 | — | — | CN | claimed |
| US-20220288157-A1 | SMALL MOLECULE SUPPRESSORS OF APOE GENE EXPRESSION AND CEREBRAL VASCULAR AMYLOID PATHOLOGY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-15 | — | — | US | claimed |
| WO-2022192716-A1 | SMALL MOLECULE SUPPRESSORS OF APOE GENE EXPRESSION AND CEREBRAL VASCULAR AMYLOID PATHOLOGY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-15 | — | — | WO | claimed |
| CN-112358532-A | Closed cycle high-speed countercurrent chromatography for preparing cyclosporine D | 浙江省林业科学研究院 | 2021-02-12 | — | — | CN | claimed |
| EP-2931299-B1 | NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE | PERIOC LTD (GB) | 2019-02-06 | — | — | EP | claimed |
| CN-108715606-A | The method of the cyclic annular ten monoamino-acid peptides of production | 诺华股份有限公司 | 2018-10-30 | — | — | CN | claimed |
| US-10065992-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2018-09-04 | — | — | US | claimed |
| WO-1997018828-A1 | INHIBITORS OF CYCLOPHILIN ROTAMASE ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-05-29 | — | — | WO | claimed |
| WO-1997015269-A2 | METHOD, COMPOSITIONS AND KITS FOR INCREASING THE ORAL BIOAVAILABILITY OF PHARMACEUTICAL AGENTS | BAKER NORTON PHARMACEUTICALS, INC. (US) | 1997-05-01 | — | — | WO | claimed |
| EP-0760237-A1 | Oil-in-water microemulsions | CIPLA LIMITED (IN) | 1997-03-05 | — | — | EP | claimed |
| US-5051402-A | Fungicides, immunosuppressants and antiphlogistic agents | SANKYO COMPANY, LIMITED (JP) | 1991-09-24 | — | — | US | claimed |
| WO-1990000389-A1 | FREEZE-DRIED LIPOSOME COMPOSITIONS CONTAINING CYCLOSPORIN | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1990-01-25 | — | — | WO | claimed |
| US-4727035-A | RADIOACTIVE OR FLUORESCENT LABELS | SANDOZ LTD. (CH) | 1988-02-23 | — | — | US | claimed |
| US-4388307-A | CYCLOSPORIN WITH CARRIER OF VEGETABLE OIL, POLYALKYLENE GLYCOL TRANSESTERIFIED VEGETABLE OIL AND ETHANOL | SANDOZ LTD. (CH) | 1983-06-14 | — | — | US | claimed |
| US-4289851-A | Process for producing cyclosporin derivatives | SANDOZ LTD. (CH) | 1981-09-15 | — | — | US | claimed |
| US-4288431-A | CULTURING TOLYPLOCLADIUM, CATALYTIC HYDROGENATION, REARRANGEMENT; ANTIINFLAMMATORY, IMMUNOLOGY | SANDOZ LTD. (CH) | 1981-09-08 | — | — | US | claimed |
| US-4220641-A | CYCLOSPORIN D, DIHYDROCYCLOSPORIN D AND ISOCYCLOSPORIN D, ANTIARTHRITIC, ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE | SANDOZ LTD. (CH) | 1980-09-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12201669-B2 | Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology | APOL1, LDLR, APP | ABCB1 113/4885PPIA 1861/4885ABCC1 214/4885 |
| US-10065992-B2 | Cyclosporin analogs | CHP1, TSLP, PPP3R1 | ABCB1 777/4885PPIA 202/4885ABCC1 693/4885 |
| US-20220288157-A1 | SMALL MOLECULE SUPPRESSORS OF APOE GENE EXPRESSION AND CEREBRAL VASCULAR AMYLOID PATHOLOGY | APOL1, LDLR, APP | ABCB1 113/4885PPIA 1861/4885ABCC1 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.