SCHEMBL10137810

SCHEMBL10137810

CC(C)C(=O)c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.44
PKM P14618 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TAS1R3 Q7RTX0 8/20 0.38
TAS1R1 Q7RTX1 8/20 0.38
TAS1R2 Q8TE23 8/20 0.38
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
HTT P42858 3/20 0.34
LMNA P02545 2/20 0.32
RECQL P46063 2/20 0.32
KDM4E B2RXH2 1/20 0.32
DBH P09172 1/20 0.32
GAA P10253 1/20 0.32
TP53 P04637 1/20 0.32
MAPK1 P28482 1/20 0.32
KDM4C Q9H3R0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10137812 0.89 SMN1; SMN2 (0.41) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL10137811 0.87 FFAR1 (0.40) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL17678836 0.87 TAS1R3 (0.52) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL10137813 0.85 SMN1; SMN2 (0.42) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL10654634 0.85 FFAR1 (0.39) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL19734346 0.82 KMT2A (0.40) FFAR1PKMSMN1; SMN2TAS1R3TAS1R1
SCHEMBL14189053 0.77 SMN1; SMN2 (0.39) PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2
SCHEMBL24624146 0.76 PKM (0.33) FFAR1PKMSMN1; SMN2
SCHEMBL20508995 0.74 CES2 (0.39) PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2
SCHEMBL14519935 0.74 FFAR1 (0.42) FFAR1CES2CES1RECQLKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11673130-B2 Catalyst system containing a metathesis catalyst and at least one phenolic compound and a process for metathesis of nitrile-butadiene rubber (NBR) using the catalyst system ARLANXEO DEUTSCHLAND GMBH (DE) 2023-06-13 US disclosed
EP-2598511-B1 NOVEL STABLE AND HIGHLY TUNABLE METATHESIS CATALYSTS ECOLE NAT SUPERIEURE DE CHIMIE DE RENNES (FR) 2018-07-04 EP disclosed
US-RE43298-E1 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2012-04-03 US disclosed
US-20110117057-A1 NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS SCHERING CORPORATION (US) 2011-05-19 US disclosed
US-7595299-B2 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2009-09-29 US disclosed
US-7592316-B2 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2009-09-22 US disclosed
US-20070232549-A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION 2007-10-04 US disclosed
US-7244721-B2 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2007-07-17 US disclosed
US-20070032433-A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION CORVAS INTERNATIONAL, LTD. 2007-02-08 US disclosed
US-7169760-B2 Peptides as NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2007-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070232549-A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus HPN, TMPRSS15, VIP FFAR1 4563/4885PKM 3364/4885SMN1; SMN2 3286/4885
US-20110117057-A1 NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS HPN, TMPRSS15, VIP FFAR1 4563/4885PKM 3364/4885SMN1; SMN2 3286/4885
US-20070032433-A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus HPN, TMPRSS15, VIP FFAR1 4563/4885PKM 3364/4885SMN1; SMN2 3286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.