Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960697 | 0.80 | SMN1; SMN2 (0.34) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL18726609 | 0.76 | GAA (0.34) | ALDH1A1MAPTKMT2A | |
| SCHEMBL27644272 | 0.76 | L3MBTL1 (0.44) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL22019074 | 0.73 | NPC1 (0.38) | ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL23871973 | 0.73 | TP53 (0.43) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL26814125 | 0.73 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2RECQLMAPTPOLB | |
| SCHEMBL19512667 | 0.72 | NFKB1 (0.40) | ALDH1A1 | |
| SCHEMBL24398318 | 0.71 | EPHX2 (0.43) | ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL6365369 | 0.70 | CA12 (0.31) | ALDH1A1 | |
| SCHEMBL6365373 | 0.70 | CA12 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-05-06 | — | — | EP | disclosed |
| WO-2012007493-A1 | PURINE COMPOUNDS SELECTIVE FOR ΡI3Κ P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| EP-2013202-B1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2010-06-16 | — | — | EP | disclosed |
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | disclosed |