Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978314 | 0.83 | KDM4C (0.53) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL10172663 | 0.80 | MAPT (0.51) | ALDH1A1SMN1; SMN2LMNAMAPTALPL | |
| SCHEMBL8842823 | 0.70 | RAB9A (0.50) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL8889163 | 0.69 | MEN1 (0.50) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL8889349 | 0.69 | ALDH1A1 (0.48) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL10172532 | 0.68 | HPGDS (0.60) | MAPK1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL23294606 | 0.68 | ALPL (0.49) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL30639651 | 0.67 | ACHE (0.50) | MEN1KMT2AMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10962555 | 0.67 | MEN1 (0.47) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL28749489 | 0.67 | MAP2K4 (0.51) | MEN1KMT2AMAPK1MAP2K4MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148363-B2 | Heterocyclic compounds as factor IXA inhibitors | SCHERING CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | F9, F12, F8 | MEN1 994/4885KMT2A 2422/4885MAPK1 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.