SCHEMBL10145000

SCHEMBL10145000

CCN(C)c1ccc(C=NN(Cc2ccccc2)c2ccccc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.77
KMT2A Q03164 7/20 0.77
MEN1 O00255 6/20 0.77
MCL1 Q07820 2/20 0.77
SMN1; SMN2 Q16637 2/20 0.77
MAPT P10636 10/20 0.66
GAA P10253 2/20 0.66
HSP90AA1 P07900 1/20 0.66
G6PC1 P35575 6/20 0.56
LMNA P02545 6/20 0.54
MAPK1 P28482 5/20 0.54
POLB P06746 3/20 0.54
PKM P14618 1/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
ATM Q13315 1/20 0.54
KDM4E B2RXH2 5/20 0.49
HPGD P15428 3/20 0.45
TDP1 Q9NUW8 3/20 0.45
MITF O75030 1/20 0.45
RAD52 P43351 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1702643 0.87 ALDH1A1 (0.74) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL1056798 0.87 ALDH1A1 (0.74) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL130652 0.87 ALDH1A1 (0.78) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL14337651 0.86 ALDH1A1 (0.72) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL9809671 0.83 MAPT (0.79) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL9809673 0.83 MAPT (0.79) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL16425719 0.81 MAPT (0.49) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL11238435 0.80 MAPT (1.00) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL11238432 0.80 MAPT (1.00) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2
SCHEMBL8499120 0.80 MAPT (0.73) ALDH1A1KMT2AMEN1MCL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178266-B2 Electrophotographic photoreceptor, image forming apparatus using the electrophotographic photoreceptor, and method of producing electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-20090324281-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS USING THE ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2009-12-31 US disclosed