Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695012 | 0.91 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815987 | 0.91 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695360 | 0.84 | PIK3R2 (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10147643 | 0.84 | PIK3R2 (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10146911 | 0.77 | HPGD (0.46) | PIK3CD | |
| SCHEMBL10147644 | 0.76 | PIK3CD (0.42) | PIK3CDPIK3CGMAP4K4 | |
| SCHEMBL1695013 | 0.75 | PTGES (0.41) | PTGESPIK3R2PIK3CDPIK3CG | |
| SCHEMBL10146891 | 0.74 | PIK3R2 (0.35) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10147661 | 0.74 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695240 | 0.74 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |